J. G. Sanchez León, J. M. Rodriguez Diaz

En trabajadores expuestos a la inhalación de sustancias radiactivas normalmente se realiza un control consistente en la realización de bioensayos (e.j: medida de U en orina) a partir de los cuales se estima la cantidad total Bi incorporada en un intervalo de tiempo Ti. Para ellos se utilizan modelos biocinéticos, en estos modelos habitualmente se supone la incorporación diaria μi durante Ti es constante dada por μi = Bi/Ti. Con este criterio, en trabajos previos se ha estimado por DOE los momentos mas adecuados para tomar las medidas: {m1, ..mj}. Una aproximación más realista es considerar μi corresponde al promedio de las incorporaciones diarias bj que son aleatorias, y además durante Ti hay días sin incorporación. Con este criterio se ha desarrollado un método para estimar las excreciones urinarias diarias y sus intervalos de confianza. Se pretende estimar por DOE los momentos óptimos para tomar las muestras en esta circunstancias (b aleatorias y periodos sin exposición)

Keywords: Diseño, incertidumbres, modelización

Scheduled

GT07 Design of Experiments I
June 8, 2022  12:40 PM
Conference hall


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