Application of machine learning and Cox regression algorithms to survival and risk analysis of molecular subtypes of Colorectal Cancer
J. M. Sánchez Santos, A. Berral-Gonzalez, S. Bueno-Fortes, M. Martin-Merino, J. De Las Rivas
We obtained and validated in a cohort of 1273 tumor samples from colorectal cancer (CRC) patients a signature of differentially expressed genes that was determined in human colon cell lines laking gene CDKN1A. The cohort is composed of normalized transcriptomic data together with phenotypic and survival data. We classified patients into the four Consensus Molecular Subtypes (CMS) of CRC reported by using independent algorithms to achieve robust results: CMScaller (uses Nearest Template Prediction (NTP) algorithm) and CMSclassifier (uses Random Forest). This approach yields us 854 samples classified in consensus. We performed risk analysis of the samples classified as CMS1 and CMS4 using machine learning. Finally, we used the validated gene signature from the cell line CDKN1A to obtain separability in the Kaplan-Meier curves in a meaningful way. Also, we performed a classification of patients based on their risk obtaining a signature of genes that most influence this separability.
Keywords: machine learning, random forest, survival analysis, classification, colorectal cancer, transcriptomic data
Scheduled
Posters II
June 7, 2022 4:50 PM
Faculty Hall
Other papers in the same session
A. J. Fernández Ares, N. Rico Castro, D. Romero Molina
J. M. Gutiérrez Expósito, L. A. San José Nieto, B. Abdul-Jalbar Betancor, J. Sicilia Rodríguez
L. Aromi Leaverton, C. Casacuberta Vergés, D. Farré Gil, Y. A. Katz, J. Vives Santa-Eulalia, J. Vives Santa-Eulalia
A. F. Roldán López de Hierro, M. M. Rueda García, M. Sánchez Maldonado, C. Roldán
Ú. Torres Parejo, R. Enrique Guillén, M. D. Ruiz Jiménez
J. Navarro, J. Mulero González
Latest news
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6/8/22
Visit Alhambra
Tomorrow, Thursday, we will visit the Alhambra. 1. At 7:00 p.m., buses will start leaving from the door of the Hotel Granada Center (in front of the door of the Faculty of Sciences) 2. Upon arrival, groups with guides will be organized. 3. There will be groups in English language. These groups will wait at the destination until the arrival of all buses. 4. After the visit to the Alhambra we will walk to the Carmen de los Mártires to have a cocktail. 5. On the way back, we can go back by bus, which will leave from the same place where they left us at the Alhambra. 6. Although the way to the Alhambra by bus seems long, it really is close to the city. We invite you, whoever wishes, to go down for a pleasant walk. 7. Do not forget to take your Alhambra ticket and your identity card or passport. The document must be the same whose number matches the ticket number you have.
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5/31/22
YouTube Channel
The menu label is already on the web from where you can see the live broadcasts: inauguration, plenary sessions, round tables,... Don't forget to enter the YouTube channel and subscribe!!!!
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5/27/22
Gala Dinner
It opens the possibility that anyone who is registered for the conference, and wants non-registered companions to attend the gala dinner, can do so by paying the price of this dinner (80 euros VAT included). This payment must be made before June 1 (inclusive). To do this, contact with [email protected]
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5/23/22
IMPORTANT WARNING
To access the Alhambra on the visit on Thursday 9, it is obligatory to present the identification document whose reference was sent to the organization (eurocongress)
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5/16/22
Social Events
All social events are included with the payment of the corresponding registration.
