M. T. Santos Martín, J. M. Rodriguez Diaz, I. Mariñas del Collado

El modelo lineal que calcula el nivel de alcoholemia en su fase de eliminación tras el consumo de alcohol, formulado por Widmark, puede resultar insuficiente si los controles se realizan en las primeras fases tras la ingesta de las bebidas alcohólicas. Modelos no lineales para modelizar el nivel de alcohol han sido estudiados desde el punto de vista del diseño óptimo para determinar los tiempos de observación que den la mejor estimación de los parámetros en los modelos no lineales, los cuales se encuentran influenciados por muchos factores: cantidad de alcohol ingerida, tipo de bebida consumida, el estado de ayuno, la velocidad con la que se bebe y el cuerpo de la persona (peso, edad y sexo). Para el cálculo de los diseños se tiene en cuenta la existencia de una estructura de covarianza entre las observaciones al estar tomadas sobre un mismo sujeto.

Keywords: Diseño óptimo de experimentos, D-optimalidad, alcohol, Widmark

Scheduled

GT07 Design of Experiments III
June 8, 2022  5:20 PM
Conference hall


Other papers in the same session


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