Analyzing omics data from clinical interventions with ASCA
J. Camacho Páez, C. Díaz, P. Sánchez Rovira
Analysis of Variance Simultaneous Component Analysis (ASCA) is a multivariate methodology that combines the variance factorization and statistical inference capability of the Analysis of Variance (ANOVA) with the exploratory data analysis power of Principal Component Analysis (PCA). Permutation tests are the standard technique for significance testing in ASCA. In this presentation, we focus on longitudinal intervention studies with multivariate outcomes, a relevant experimental design in clinical studies where the outcome is an omics profile (such as in genomics, metabolomics, and the like). We show that choosing the best permutation approach is far from intuitive and that there is a significant risk of deriving incorrect conclusions in real-life analyses.
Keywords: ASCA, Permutation Tests, Longitudinal Intervention Studies, Omics, Power Analysis, Power Curves
Scheduled
Multivariate Analysis II
June 8, 2022 5:20 PM
Cloister room
Other papers in the same session
S. Pérez Fernández, P. Martínez Camblor, N. Corral Blanco
C. Matrán Bea, D. Rodríguez Vítores
J. J. Egozcue, V. Pawlowsky-Glahn
Latest news
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6/8/22
Visit Alhambra
Tomorrow, Thursday, we will visit the Alhambra. 1. At 7:00 p.m., buses will start leaving from the door of the Hotel Granada Center (in front of the door of the Faculty of Sciences) 2. Upon arrival, groups with guides will be organized. 3. There will be groups in English language. These groups will wait at the destination until the arrival of all buses. 4. After the visit to the Alhambra we will walk to the Carmen de los Mártires to have a cocktail. 5. On the way back, we can go back by bus, which will leave from the same place where they left us at the Alhambra. 6. Although the way to the Alhambra by bus seems long, it really is close to the city. We invite you, whoever wishes, to go down for a pleasant walk. 7. Do not forget to take your Alhambra ticket and your identity card or passport. The document must be the same whose number matches the ticket number you have.
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5/31/22
YouTube Channel
The menu label is already on the web from where you can see the live broadcasts: inauguration, plenary sessions, round tables,... Don't forget to enter the YouTube channel and subscribe!!!!
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5/27/22
Gala Dinner
It opens the possibility that anyone who is registered for the conference, and wants non-registered companions to attend the gala dinner, can do so by paying the price of this dinner (80 euros VAT included). This payment must be made before June 1 (inclusive). To do this, contact with [email protected]
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5/23/22
IMPORTANT WARNING
To access the Alhambra on the visit on Thursday 9, it is obligatory to present the identification document whose reference was sent to the organization (eurocongress)
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5/16/22
Social Events
All social events are included with the payment of the corresponding registration.
