CIRCUST, the circular-based methodology that reveals human circadian biology
Y. Larriba, C. Rueda
Peaks of gene expressions are crucial in circadian biology as it determines the time of day when the gene biological function is performed. The 50% of gene expressions in mammals display rhythmic patterns, with expressions varying across tissues. Due to the risk that it entails, in most human gene studies sampling times are unrecorded. This work proposes CIRCUST, a methodology that robustly estimates the temporal order among samples and accurately analyzes molecular rhythms. It relies on the formulation of the problem within the Circular Space and on the use of non-linear models for the analysis of oscillatory signals. CIRCUST has been validated on two controlled experiments. Its great performance is demonstrated for the GTEx database, with high inter-individual variability. For 34 human tissues, the temporal order estimation problem is solved, molecular rhythms are analyzed and clock molecular networks are described to provide, as a culmination, an atlas of human circadian expressions
Keywords: Temporal Order Estimation, Oscillatory Signal Analysis, Non Linear Models, Circular Principal Components, Gene Expression Analysis, Circadian Rhythms
Scheduled
Biostatistics I
June 9, 2022 10:10 AM
A13
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A. Garcia Hernandez, T. Perez Perez, D. Rizopoulos, M. C. Pardo Llorente
A. García Burgos, B. González Alzaga, M. J. Jiménez Asensio, M. Lacasaña Navarro, N. Rico Castro, D. Romero Molina
F. Castro-Prado, D. Edelmann, J. J. Goeman
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6/8/22
Visit Alhambra
Tomorrow, Thursday, we will visit the Alhambra. 1. At 7:00 p.m., buses will start leaving from the door of the Hotel Granada Center (in front of the door of the Faculty of Sciences) 2. Upon arrival, groups with guides will be organized. 3. There will be groups in English language. These groups will wait at the destination until the arrival of all buses. 4. After the visit to the Alhambra we will walk to the Carmen de los Mártires to have a cocktail. 5. On the way back, we can go back by bus, which will leave from the same place where they left us at the Alhambra. 6. Although the way to the Alhambra by bus seems long, it really is close to the city. We invite you, whoever wishes, to go down for a pleasant walk. 7. Do not forget to take your Alhambra ticket and your identity card or passport. The document must be the same whose number matches the ticket number you have.
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5/31/22
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5/27/22
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5/23/22
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5/16/22
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