A. García Burgos, N. Rico Castro, D. Romero Molina, B. González Alzaga, M. J. Jiménez Asensio, M. Lacasaña Navarro

Partiendo de una cohorte de mujeres embarazadas estudiada de forma longitudinal se intenta conocer cómo afecta la exposición de las madres y sus hijos a sustancias ambientales contaminantes y otros factores y hábitos. Se trabaja con biometrías ecográficas donde la información de los casos no coincide en edad gestacional ni en la frecuencia con se que realizan las medidas. Para homogeneizar los tiempos de observación, se propone la imputación de datos en tres instantes de tiempo, iguales y únicos, para cada uno de los casos estudiados. El procedimiento para realizar esta imputación consiste en ajustar un modelo que permita una estructura de autocorrelación entre los residuos y permita la falta de homocedasticidad. En particular, se han utilizado modelos lineales de mínimos cuadrados generalizados con variables confusoras seleccionadas a partir de un método de inclusión por pasos. Esto permite el estudio del efecto de los diferentes factores en el crecimiento fetal.

Keywords: Medidas ecográficas, imputación, curva de crecimiento, modelo lineal de mínimos cuadrados generalizado

Scheduled

Biostatistics I
June 9, 2022  10:10 AM
A13


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